The result of your variant on RNA or protein functionality, according to experimental evidence from submitters.
This worth is calculated by NCBI depending on info from submitters. Study our guidelines for calculating the review position. The quantity of submissions which contribute to this critique status is shown in parentheses.
There is no purposeful proof in ClinVar for this variation. Should you have produced purposeful details for this variation, you should take into consideration submitting that details to ClinVar.
This column includes more info supporting the classification, like citations, the comment on classification, and specific evidence delivered as observations on the variant through the submitter.
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The combination germline classification for this variant, usually for the monogenic or Mendelian ailment as in the ACMG/AMP recommendations, or for reaction to your drug. This price is calculated by NCBI depending on knowledge from submitters. Read our policies for calculating the mixture classification.
There aren't any citations for germline classification of the variant in ClinVar. If you are aware thr777 of of citations for this variation, be sure to consider publishing that information to ClinVar.
The number of variants in ClinVar which can be contained inside of this gene, having a hyperlink to view the list of variants.
These citations are discovered by LitVar using the rs range, so they may incorporate citations for multiple variant at this area. Be sure to assessment the LitVar effects very carefully for your personal variant of interest. File past updated Could 19, 2024
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Stars signify the combination critique status, or the extent of overview supporting the mixture germline classification for this VCV record.
The positioning is protected. The https:// guarantees that you will be connecting towards the official Web page and that any data you provide is encrypted and transmitted securely.
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Stars symbolize the critique status, or the extent of evaluation supporting the submitted (SCV) file. This worth is calculated by NCBI depending on info from the submitter.